Rheumatoid arthritis (RA)
Ru-Rong Ji, PhD
Duke University School of Medicine
Durham, NC, United States
Disclosure(s): Boston Scientific Inc: Consultant (Ongoing), Grant/Research Support (Ongoing)
Rachel Miller, PhD, BS
Rush University Medical Center
Chicago, IL, United States
Disclosure(s): No financial relationships with ineligible companies to disclose
Theodore Price, PhD
University of Texas, Dallas
Richardson, TX, United States
Disclosure(s): 4E Therapeutics: Advisor or Review Panel Member (Ongoing), Intellectual Property/Patents (Ongoing), Ownership Interest (Ongoing); AbbVie/Abbott: Grant/Research Support (Ongoing); Doloromics: Advisor or Review Panel Member (Ongoing), Ownership Interest (Ongoing); Grunenthal: Grant/Research Support (Ongoing); Hoba Therapeutics: Grant/Research Support (Ongoing); Merck: Grant/Research Support (Ongoing); PARMedics: Advisor or Review Panel Member (Ongoing), Ownership Interest (Ongoing)
Chronic pain associated with joint disorders, such as rheumatoid arthritis (RA), osteoarthritis (OA), and other rheumatic diseases, is a highly debilitating symptom that impacts mobility and quality of life in affected patients. Emerging evidence suggests that rheumatic pain and joint inflammation are at least partially uncoupled consequences that need better understanding for effective treatment. The goal of this session is to bring together some interesting cellular and molecular understandings of the neuroimmune interplay in joint pain. This session will bring together three researchers from chronic pain in musculoskeletal diseases to provide recent basic and translational advancements in the field. The first speaker will provide insights into the novel concept that the pain pathway constitutes an integral part of the failing joint as an organ by highlighting the relationship between progressive joint damage in OA and pain pathways. The second speaker will shed some light on the recent research on inflammation-independent mechanisms of RA pain using mouse genetics and behavioral approaches in an effort to illuminate novel peripheral neural mechanisms underlying RA pain. The third speaker will provide insights on the topics of chronic pain mechanisms and the development of novel pain therapeutics and their potential application in rheumatic diseases.
Speaker: Rachel Miller, PhD, BS – Rush University Medical Center
Speaker: Theodore Price, PhD – University of Texas, Dallas
Speaker: Ru-Rong Ji, PhD – Duke University School of Medicine
