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Scientific Session

Immunobiology
General Topic: Basic Science

14T180: More Than Complementary Pathways: Where Coagulation and Complement Converge

Tuesday, November 14, 2023
4:00 PM – 5:30 PM PT
Location: Room 31A-C
CE: 1.5

In Person On Demand

    Speaker(s)

  • KM

    Keith McCrae, MD

    Cleveland Clinic
    Cleveland, OH, United States

    Disclosure(s): Argenex: Advisor or Review Panel Member (Ongoing); Novartis: Advisor or Review Panel Member (Terminated, April 22, 2023), Consultant (Terminated, April 22, 2023); Sanofi: Advisor or Review Panel Member (Ongoing), Consultant (Ongoing); Sobi: Consultant (Ongoing), Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Ongoing)

  • FT

    Francesco Tedesco, MD

    Istituto Auxologico Italiano, IRCCS, Milan, Italy
    TS - Trieste, Trieste, Italy

    Disclosure(s): No financial relationships with ineligible companies to disclose

  • JT

    Joshua Thurman, MD

    University of Colorado
    Aurora, CO, United States

    Disclosure(s): Q32 Bio, Inc.: Consultant (Ongoing), Royalties (Ongoing), Stock options or bond holdings in a for-profit corporation or self-directed pension plan (Ongoing)

Complement and coagulation are interconnected proteolytic cascades that are required to mediate wound healing and prevent excessive bleeding but can become dysregulated, leading to abnormal clotting and tissue inflammation. Examples of relevant diseases are antiphospholipid syndrome, thrombotic microangiopathy, and placental injury mediated by antiphospholipid antibodies. This session will address new insights into the interaction of complement and coagulation cascades and potential mechanisms of tissue injury.

Learning Objectives:

  • Summarize the complement and coagulation pathways and how they intersect and influence each other.
  • Learn how the complement pathway amplifies pregnancy complications in rheumatic diseases and potential new therapies.
  • Understand how antiphospholipid antibodies injure the placenta.

Presentations:

  • 4:00 PM – 4:20 PM PT
    Intersection of the Complement and Coagulation Pathways

    Speaker: Keith McCrae, MD – Cleveland Clinic

  • 4:20 PM – 4:30 PM PT
    Q&A
  • 4:30 PM – 4:50 PM PT
    Crosstalk Between the Complement and Coagulation Systems in Antiphospholipid Syndrome

    Speaker: Francesco Tedesco, MD – Istituto Auxologico Italiano, IRCCS, Milan, Italy

  • 4:50 PM – 5:00 PM PT
    Q&A
  • 5:00 PM – 5:20 PM PT
    Complement, Coagulation, and the Kidney

    Speaker: Joshua Thurman, MD – University of Colorado

  • 5:20 PM – 5:30 PM PT
    Q&A