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Scientific Session

Rheumatoid arthritis (RA)
General Topic: Basic Science

14T144: Reconstructing Rheumatoid Arthritis Through Space and Time. New Insights into RA Pathology from the AMP RA/SLE Consortium

Tuesday, November 14, 2023
2:00 PM – 3:00 PM PT
Location: Room 23A-C
CE: 1

In Person On Demand

    Speaker(s)

  • Andrew Filer, MD, PhD, FRCP

    The University of Birmingham
    Birmingham, United Kingdom

    Disclosure(s): Bristol-Myers Squibb(BMS): Grant/Research Support (Ongoing); GlaxoSmithKlein(GSK): Grant/Research Support (Ongoing); Janssen: Grant/Research Support (Ongoing); Nascient: Grant/Research Support (Ongoing); Sonoma Biotherapeutics: Consultant (Ongoing)

  • Deepak Rao, MD, PhD

    Brigham and Women's Hospital
    Boston, MA, United States

    Disclosure(s): AstraZeneca: Consultant (Ongoing); Bristol-Myers Squibb: Consultant (Ongoing), Grant/Research Support (Ongoing); GlaxoSmithKlein(GSK): Consultant (Terminated, April 6, 2023); Hifibio: Consultant (Ongoing); Janssen: Grant/Research Support (Ongoing); Merck: Grant/Research Support (Ongoing); Scipher Medicine: Consultant (Ongoing)

  • KW

    Kathryn Weinand, BS

    Harvard University
    Jamaica Plain, MA, United States

    Disclosure(s): No financial relationships with ineligible companies to disclose

This session will present the newest wave of discoveries from the multi-institution Accelerating Medicines Partnership RA/SLE consortium study of rheumatoid arthritis. This year, the focus is on new technologies not previously revealed, including single-cell ATACseq and B- and T-cell repertoire studies, which provide deeper insights into the pathogenesis of RA and the plasticity and migration of the cell types. Stromal cells, such as fibroblasts and endothelial cells, are now increasingly recognized as drivers of inflammation and tissue damage. Imaging, including both traditional immunofluorescence and cutting-edge, high-dimensional imaging mass cytometry, provide new insights into the architecture of RA synovium. Single-cell ATACseq provides insight into the chromatin state and transcriptomic potential of cells in synovial tissue, providing insights into the single-cell transcriptomic data provided by RNAseq and a new way of connecting cell states and subsets. Together, these studies provide deeper insights into RA pathogenesis than ever before, and provide a framework with which to approach studies of other autoimmune diseases.

Learning Objectives:

  • Identify the cellular components of hallmark histologic features of RA synovium.
  • Understand the effects of fibroblasts, endothelial cells, T-cells, and B-cells on driving inflammation and shaping synovial tissue architecture.
  • Summarize epigenetic findings in RA synovium and their potential implications for RA pathogenesis.

Presentations:

  • 2:00 PM – 2:15 PM PT
    Insights from B and T Cell Repertoire Studies in Rheumatoid Arthritis Blood and Synovium

    Speaker: Deepak Rao, MD, PhD – Brigham and Women's Hospital

  • 2:15 PM – 2:30 PM PT
    Epigenetics of Synovitis: Atacseq and Next Generation Omics Studies in RA

    Speaker: Kathryn Weinand, BS – Harvard University

  • 2:30 PM – 2:45 PM PT
    Cellular Architecture of Synovitis: Imaging of Rheumatoid Arthritis Synovium

    Speaker: Andrew Filer, MD, PhD, FRCP – The University of Birmingham

  • 2:45 PM – 3:00 PM PT
    Q&A