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Final Program


Schedule at a Glance
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Session Format
In Person
In Person
Livestreamed
Livestreamed
On Demand
On Demand
Scientific Session

Osteoarthritis (OA) and related disorders
General Topic: Basic Science

12S135: Breaking down Osteoarthritis at the Single Cell Level

Sunday, November 12, 2023
2:00 PM - 3:00 PM PT
Location: Room 8
CE: 1

In Person On Demand

    Speaker(s)

  • C. Thomas Appleton, MD, PhD, FRCPC

    The University of Western Ontario
    London, ON, Canada

    Disclosure(s): AbbVie/Abbott: Advisor or Review Panel Member (Ongoing), Consultant (Ongoing), Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Ongoing); AstraZeneca: Advisor or Review Panel Member (Ongoing), Advisor or Review Panel Member (Ongoing); Celgene: Advisor or Review Panel Member (Ongoing); Eli Lilly: Advisor or Review Panel Member (Ongoing); Janssen: Advisor or Review Panel Member (Ongoing); Novartis: Advisor or Review Panel Member (Ongoing), Consultant (Ongoing), Grant/Research Support (Ongoing), Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Ongoing); Pfizer: Advisor or Review Panel Member (Ongoing), Consultant (Ongoing), Grant/Research Support (Ongoing), Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Ongoing); Roche: Advisor or Review Panel Member (Ongoing); UCB: Advisor or Review Panel Member (Ongoing), Consultant (Ongoing), Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Ongoing)

  • NB

    Nidhi Bhutani, PhD

    Stanford University
    Stanford, CA, United States

    Disclosure(s): No financial relationships with ineligible companies to disclose

  • CD

    Cosimo De Bari, MD, PhD, FRCP

    University of Aberdeen
    Aberdeen, United Kingdom

    Disclosure(s): Biosplice: Grant/Research Support (Ongoing); Galapagos: Consultant (Ongoing), Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Ongoing); UCB: Consultant (Terminated, March 9, 2021)

This session will provide the most recent updates in the pathobiology of osteoarthritis resulting from state of the art transcriptomic data on synovial cells and chondrocytes that impact pain and disease progression.

Learning Objectives:

  • Review the recent synovial transcriptomic data in human osteoarthritis as it relates to pain
  • Describe the interplay of chondrocyte populations with synoviocytes in osteoarthritis
  • Describe synovial cell diversity in post-traumatic osteoarthritis

Presentations:

  • 2:00 PM - 2:15 PM PT
    Insights into the Pathobiology of Pain in Joint Diseases from Molecular Spatial and Single Cell Profilin

    Speaker: C. Thomas Appleton, MD, PhD, FRCPC – The University of Western Ontario

  • 2:15 PM - 2:30 PM PT
    Preclinical Osteoarthritis Drug Screening with Single-Cell Mass Cytometry

    Speaker: Nidhi Bhutani, PhD – Stanford University

  • 2:30 PM - 2:45 PM PT
    Distinct Populations of Fibroblast-Like Synoviocytes in Healthy and Injured Knees

    Speaker: Cosimo De Bari, MD, PhD, FRCP – University of Aberdeen

  • 2:45 PM - 3:00 PM PT
    Q&A