14T152: Abstracts: Muscle Biology, Myositis & Myopathies – Basic & Clinical Science I (2461–2466)

Presenting Author(s)

• LB

  Lindsay Bass, BS (she/her/hers)

  Vanderbilt University
  Nashville, TN, United States

  Disclosure information not submitted.
• JG

  Jorge Gonzalez Chapa, MD, PhD

  University of Washington
  Seattle, WA, United States

  Disclosure information not submitted.
• IP

  Iago Pinal-Fernandez, MD, PhD

  National Institutes of Health
  Bethesda, MD, United States

  Disclosure information not submitted.
• JT

  Jule Taubmann, MD, BSc

  Universitätsklinikum Erlangen
  Erlangen, Germany

  Disclosure information not submitted.
• EV

  Eveline Van Gompel, MSc

  KU Leuven - Karolinska Institutet
  Leuven, Belgium

  Disclosure information not submitted.
• EW

  Erin Wilfong, MD, PhD (she/her/hers)

  Vanderbilt University Medical Center
  Nashville, TN, United States

  Disclosure(s): Boehringer-Ingelheim: Advisor or Review Panel Member (Ongoing), Grant/Research Support (Ongoing), Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Ongoing); Cabaletta Bio: Advisor or Review Panel Member (Ongoing)

Abstract oral session.

Non-CME

Presentations:

• 2:00 PM - 2:10 PM PT

  Transcriptional Derepression of CHD4/NuRD-regulated Genes in the Muscle of Patients with Dermatomyositis and anti-Mi2 Autoantibodies
  

  Presenting Author: Iago Pinal-Fernandez, MD, PhD – National Institutes of Health
• 2:10 PM - 2:15 PM PT

  Q&A
  
• 2:15 PM - 2:25 PM PT

  Mitochondrial-Mediated Neutrophil Activation in Dermatomyositis (DM) and Inclusion Body Myositis (IBM): Insights into Pathogenesis and Therapeutic Implications
  

  Presenting Author: Jorge Gonzalez Chapa, MD, PhD – University of Washington
• 2:25 PM - 2:30 PM PT

  Q&A
  
• 2:30 PM - 2:40 PM PT

  Efficacy and Safety of Car-T-Cell Treatment in Refractory Antisynthetase Syndrome – Data of the First Three Patients
  

  Presenting Author: Jule Taubmann, MD, BSc – Universitätsklinikum Erlangen
• 2:40 PM - 2:45 PM PT

  Q&A
  
• 2:45 PM - 2:55 PM PT

  B Cells in Anti-tRNA Synthetase Syndrome Patients Show an Activated, Interferon Responsive Signature
  

  Presenting Author: Erin Wilfong, MD, PhD (she/her/hers) – Vanderbilt University Medical Center
• 2:55 PM - 3:00 PM PT

  Q&A
  
• 3:00 PM - 3:10 PM PT

  Clonally Expanded B Cells in Anti-Histidyl-tRNA Synthetase Syndrome Patients Exhibit an Autoreactive-Prone Memory Phenotype and Bind Jo-1 Autoantigen
  

  Presenting Author: Lindsay Bass, BS (she/her/hers) – Vanderbilt University
• 3:10 PM - 3:15 PM PT

  Q&A
  
• 3:15 PM - 3:25 PM PT

  Monoclonal Anti-MDA5 Autoantibodies Derived from a Patient with Dermatomyositis Target the Hel2i Domain of the MDA5 Protein
  

  Presenting Author: Eveline Van Gompel, MSc – KU Leuven - Karolinska Institutet
• 3:25 PM - 3:30 PM PT

  Q&A