2372: Soluble Triggering Receptor Expressed on Myeloid Cell-1 Reflects the Cross-sectional Activity of Microscopic Polyangiitis and Granulomatosis with Polyangiitis
Yonsei university college of medicine Seodaemun-gu, Seoul, South Korea
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Jang Woo Ha1, Jason Jungsik Song2, Yong-Beom Park2, Sung Soo Ahn2 and Sang-Won Lee3, 1Yonsei University College of Medicine, Seodaemun-gu, Seoul, South Korea, 2Yonsei University College of Medicine, Seoul, South Korea, 3Yonsei University College of Medicine, Seoul, South Korea
Background/Purpose: This study investigated whether the soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) reflects the cross-sectional activity of microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA).
Methods: This study included 47 MPA and 32 GPA patients with well-documented clinical records and stored sera at diagnosis. The activity of vasculitis was assessed using the Birmingham vasculitis activity score (BVAS) The patients were arbitrarily divided into two groups according to BVAS at a frequency of 50% as the upper and lower halves of BVAS.
Results: The median age of the 79 patients was 67.0 years, and 58.2% were women. The median BVAS and sTREM-1 were 12.0 and 513.5 pg/mL. sTREM-1 was significantly correlated with BVAS along with five-factor score, short Form 36 health survey, and C-reactive protein. In the multivariable linear regression analysis, erythrocyte sedimentation rate (standardised β 0.241), and sTREM-1 (standardised β 0.288) were independently correlated with BVAS. Using the receiver operator characteristic curve, the cut-off of sTREM-1 for the upper half of BVAS was set as 474.1 pg/mL. When we divided patients into two groups based on sTREM-1 ≥474.1 pg/mL, MPA and GPA patients with sTREM-1 ≥474.1 pg/mL exhibited a significantly higher risk for the upper half of BVAS than those without (relative risk 5.932). In the multivariable logistic regression analysis with sTREM-1 ≥474 pg/mL, sTREM-1 ≥474 pg/mL (OR 5.662) was independently associated with the upper half of BVAS.
Conclusion: This study is the first to demonstrate that sTREM-1 reflects the cross-sectional activity of MPA and GPA.
Table 1. Linear regression analysis of variables for BVAS in patients with MPA and GPA
Table 2. Logistic regression analysis of variables for the upper half of BVAS in patients with MPA and GPA
Figure 1. Optimal cut-off and relative risk. (A) Using the ROC curve, sTREM-1 of 474.1 pg/ml was set as the cut-off for the upper half of BVAS. (B) MPA and GPA patients with sTREM-1 ≥474.1 pg/mL exhibited a significantly higher risk for the upper half of BVAS than those without. ROC: receiver operator characteristic; sTREM-1: soluble triggering receptor expressed on myeloid cells-1; BVAS: Birmingham vasculitis activity score; MPA: microscopic polyangiitis; GPA: granulomatosis with polyangiitis.
J. Ha: None; J. Song: None; Y. Park: None; S. Ahn: None; S. Lee: None.
