1953: Mortality Trends in Polymyositis and Dermatomyositis in Mexico: A General Population-based Study from 2000 to 2019

CLAUDIA MENDOZA PINTO¹, Pamela Munguía-Realpozo¹, Ivet Etchegaray-Morales², Mario García-Carrasco², Paulina Cortés-Hernández¹, Roberto Arreguín-Reyes¹, Jorge Ayón-Aguilar¹ and Gabriel Rodríguez-Castillo², ¹Instituto Mexicano del Seguro Socia, Puebla, Mexico, ²Medicine School, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico

Background/Purpose: Patients with polymyositis and dermatomyositis (PM/DM) present multiple complications that may lead to increased mortality rates and data on PM/DM mortality in Mexico is lacking.
The objective of this study was to assess mortality trends in PM/DM idiopathic inflammatory myopathies (IMM) in Mexico between 2000 and 2019, overall and by sex, age group, and geographic regions.

Methods: Data were acquired from the General Board of Health Information Open Access databases, and we identified deaths for PM/DM (ICD codes, 10^th edition), which were recorded from 2000 to 2019 from all public hospitals nationwide. Age-standardized mortality rates (ASMR) per 100,000 persons were calculated for PM/DM and non-PM/DM overall, by sexes, and by geographic region. Annual percentage change (APC) and average annual percentage change (AAPC) in ASMR were calculated using Joinpoint regression software.

Results: We found 1,456 deaths from PM/DM and 11,343,652 non-PM/DM in Mexico from 2000 and 2019. The ASMR (per 100,000 inhabitants) was 0.07 over the period. The gender distribution of PM/DM deaths was 69.8% in women and 30.2% in men. Compared to non-PM/DM, PM/DM individuals had a higher proportion in the younger population (younger than 45 years) (40.2% vs. 22.3%). Overall, a significantly downtrend in the ASMR was identified from 2007 to 2017 in subjects with PM/DM (APC -3.2%; 95% CI, -5.3 to -1.0; p = 0.008), while mortality trends were stable for non-PM/DM individuals. Similar trends were identified by sex in PM/DM patients (Fig 1). The Joinpoint analysis did not identify variation in temporal trends in mortality rates by geographic region; however, an increment in the proportion of deaths in the ratio of PM/DM to non-PM/DM ASMR from 2000 to 2019 was detected in the Northern and Southern regions (+17.6% and +84.9%, respectively).

Conclusion: Over a 20-year period, we observed that deaths due to PM/DM occurred predominantly in females. A notable decrease in overall mortality rates was identified between 2007 and 2017. Differences by sex, age, and geographic region were also detected.




C. MENDOZA PINTO: None; P. Munguía-Realpozo: None; I. Etchegaray-Morales: None; M. García-Carrasco: None; P. Cortés-Hernández: None; R. Arreguín-Reyes: None; J. Ayón-Aguilar: None; G. Rodríguez-Castillo: None.