University of Liverpool
Liverpool, United Kingdom
My core research interests are molecular mechanisms of cytokine regulation and their effects on disease expression in the spectrum from autoinflammation to autoimmunity. Special foci include the autoinflammatory bone disorder chronic nonbacterial osteomyelitis (CNO), the mixed-pattern disease psoriasis, and the prototypical autoimmune disorder systemic lupus erythematosus (SLE).
SLE is a largely T cell-mediated autoimmune disorder that can affect most organs of the human body. In my laboratory, we are investigating genetic and epigenetic variants in jSLE and their effects on age at disease-onset and associations with renal outcomes. This may allow us to predict disease courses and define therapeutic targets in the future. Another focus are transcription factor networks contributing to epigenetic alterations. Disturbed transcription factor expression and activation in T cells from SLE patients result in effector T cell phenotypes in the CD4+ and the TCR+CD3+CD4-CD8- (so-called double negative, DN) T cell compartments. Applying CRISPR/Cas9 technology, we are eliminating single transcription factors that are considered central for SLE to determine their exact contribution to altered T cell responses. We hope that our work will contribute to novel therapeutic options targeting pathological effector T cell responses in SLE and other autoimmune disorders.
Medications in Chronic Non-Bacterial Osteomyelitis: What's the Evidence?
Tuesday, November 14, 2023
11:30 AM – 11:45 AM PT
Disclosure(s): Novartis: Consultant (Terminated, August 31, 2021)
