Immunobiology
Jing Li, PhD
University of Pittsburgh
Fox Chapel, PA, United States
Disclosure(s): Mozart Therapeutics, Inc.: Royalties (Ongoing), Stock options or bond holdings in a for-profit corporation or self-directed pension plan (Ongoing)
Cory Perugino, DO
Massachusetts General Hospital
Boston, MA, United States
Disclosure(s): Horizon Therapeutics: Consultant (Ongoing)
William Robinson, MD, PhD
Stanford University
Palo Alto, CA, United States
Disclosure(s): Janssen: Grant/Research Support (Ongoing); Sanofi: Grant/Research Support (Ongoing)
This session will provide attendees with an understanding for how cytotoxic T lymphocytes (CTL) contribute to inflammation in autoimmunity. Many subsets of CD4 and CD8 T-cells are implicated in promoting disease pathogenesis by their secretion of inflammatory cytokines. Traditionally CD4 helper T-cells in the tissues have been attributed this process, but recent studies have found that cytotoxic CD8 and CD4 T-cells are key drives of inflammation. In this session, speakers will discuss the similarities and differences between cytotoxic CD4 and CD8 T-cells in different inflamed tissues. These talks will enlighten how understanding the role of CTLs in autoimmunity can lead to the discovery of potent therapeutics targeting specific T-cell populations.
Speaker: Cory Perugino, DO – Massachusetts General Hospital
Speaker: William H. Robinson, MD, PhD – Stanford University
Speaker: Jing Li, PhD – University of Pittsburgh
