Immunobiology
Cintia De Paiva, MD, PhD
Baylor College of Medicine
Houston, TX, United States
Disclosure(s): Aerie Pharmaceuticals: Grant/Research Support (Terminated, December 31, 2022); BioAegis: Grant/Research Support (Terminated, December 31, 2022); Roche: Grant/Research Support (Terminated, May 31, 2022); Serpass Biologicals: Grant/Research Support (Ongoing); Spring Discovery: Consultant (Terminated, August 31, 2022)
Mary Mattapallil, PhD
NEI/NIH
Bethesda, MD, United States
Disclosure(s): No financial relationships with ineligible companies to disclose
Anthony St. Leger, PhD
University of Pittsburgh
Pittsburgh, PA, United States
Disclosure(s): No financial relationships with ineligible companies to disclose
The eye is a complex organ with barrier, innate, and adaptive host defense systems that serve as protectors of visual function. The interplay of these interconnected systems shares overlapping features with skin and gut in more ways than previously understood. The goals of this session are to understand the mechanistic pathways involved in ocular mucosal immunity and what key contributors lead to either protection or susceptibility to the development of inflammatory or autoimmune eye disease. Parallels between skin and gut immunity, as well as the role of the microbiome in mucosal immunity, will also be discussed. The session will review overlapping immunologic mechanisms and molecular pathways in both innate and adaptive immunity that are important in corneal and retinal inflammatory disease that are seen in rheumatologic disorders. This session will also discuss the role of the microbiome and its regulation in mucosal ocular immune responses.
Speaker: Anthony St. Leger, PhD – University of Pittsburgh
Speaker: Cintia S. De Paiva, MD, PhD – Baylor College of Medicine
Speaker: Mary Mattapallil, PhD – NEI/NIH