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Final Program


Schedule at a Glance
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In Person
In Person
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Livestreamed
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On Demand
Scientific Session

Metabolic bone disease
General Topic: Basic Science

12S153: Bad to the Bone: Osteoclasts in Metabolic Bone Disease

Sunday, November 12, 2023
4:00 PM - 5:00 PM PT
Location: Room 24A-C
CE: 1

In Person On Demand

    Speaker(s)

  • MM

    Michelle Maree MCDONALD, PhD

    GARVAN INSTITUTE
    Darlinghurst, New South Wales, Australia

    Disclosure(s): No financial relationships with ineligible companies to disclose

  • SR

    Stuart Ralston, MD, FRCP, MBChB

    University of Edinburgh
    Western General Hospital, Edinburgh, United Kingdom

    Disclosure(s): AstraZeneca: Grant/Research Support (Terminated, April 30, 2023); Eli Lilly: Donation of IMP for clinical trial (Ongoing); Kyowa Kirin: Grant/Research Support (Ongoing), Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Ongoing); Novartis: Donation of IMP for clinical trial (Terminated, May 31, 2022); UCB: Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Terminated, September 14, 2022), Support to attend scientific meeting (Terminated, September 14, 2022)

  • Baohong Zhao, MD, PhD

    Hospital for Special Surgery
    New York, NY, United States

    Disclosure(s): No financial relationships with ineligible companies to disclose

Osteoclasts are multinucleated cells derived from hematopoietic precursors in the bone marrow that are characterized by their unique ability to resorb large quantities of bone. They are frequently the target of therapeutic interventions to ameliorate bone loss in osteoporosis and Paget's disease. The goal of this session is to highlight recent genetic and immunologic advances in osteoimmunology as it pertains to osteoclast function in metabolic bone disease.

Learning Objectives:

  • Identify current genetic findings and their molecular implications in Paget's disease of bone as informed by GWAS and mouse models
  • Understand the homeostatic mechanisms that affect the osteoclast lifespan and how this can be altered in metabolic bone disease, inflammation, or malignancy
  • Understand the role of hematopoiesis in osteoclast biology

Presentations:

  • 4:00 PM - 4:15 PM PT
    Paget's Disease of Bone: An Ancient Disease with Modern Genetic Findings

    Speaker: Stuart Ralston, MD, FRCP, MBChB – University of Edinburgh

  • 4:15 PM - 4:30 PM PT
    The Molecular Effects of Hematopoiesis on Osteoclastogenesis and Osteoporosis

    Speaker: Baohong Zhao, MD, PhD – Hospital for Special Surgery

  • 4:30 PM - 4:45 PM PT
    New Insights into Osteoclast Biology

    Speaker: Michelle Maree MCDONALD, PhD – GARVAN INSTITUTE

  • 4:45 PM - 5:00 PM PT
    Q&A