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Final Program


Schedule at a Glance
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In Person
In Person
Livestreamed
Livestreamed
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On Demand
Scientific Session

Genetics, genomics and proteomics
General Topic: Basic Science

12S109: De-"mystifying" Sjögren's Dryness: Molecular Interactions and Genetics Explained

Sunday, November 12, 2023
9:00 AM - 10:00 AM PT
Location: Ballroom 20A
CE: 1

In Person On Demand

    Speaker(s)

  • CD

    Cintia De Paiva, MD, PhD

    Baylor College of Medicine
    Houston, TX, United States

    Disclosure(s): Aerie Pharmaceuticals: Grant/Research Support (Terminated, December 31, 2022); BioAegis: Grant/Research Support (Terminated, December 31, 2022); Roche: Grant/Research Support (Terminated, May 31, 2022); Serpass Biologicals: Grant/Research Support (Ongoing); Spring Discovery: Consultant (Terminated, August 31, 2022)

  • CL

    Christopher Lessard, PhD

    Oklahoma Medical Research Foundation
    Oklahoma City, OK, United States

    Disclosure(s): Janssen: Grant/Research Support (Ongoing)

  • DW

    Dr. Blake M. Warner, PhD, MPH, DDS

    National Institutes of Health
    Bethesda, MD, United States

    Disclosure(s): Astellas Pharma, Inc.: Grant/Research Support (Ongoing); Pfizer: Grant/Research Support (Ongoing)

Progress in developing effective therapies for Sjögren’s syndrome has been hampered by an incomplete understanding of molecular and cellular pathophysiology in both blood and affected tissues and how this relates to heterogeneity of clinical expression. Advances in genomic, proteomic, and cellular technologies are expanding the identification of disease-associated cell types that explain clinical and molecular heterogeneity, providing new insights to guide drug development.

Learning Objectives:

  • Explain how cell type-specific genomic architecture expands the known disease-associated genes as revealed by single cell RNA sequencing of peripheral blood mononuclear cells and glandular tissue
  • Recognize that integration of spatial and single cell transcriptomic data from disease-involved tissue can elucidate disease pathophysiology in Sjogren's syndrome
  • Summarize molecularly defined subgroups of Sjogren's syndrome

Presentations:

  • 9:00 AM - 9:15 AM PT
    It's in the Loops: How Genetic Associations Point to Involvement of Specific Cell Types in Sjögren's Glandular Tissue and Blood

    Speaker: Christopher Lessard, PhD – Oklahoma Medical Research Foundation

  • 9:15 AM - 9:30 AM PT
    Identification of Sjögren's Disease-Associated Cellular Neighborhoods Using Spatial and Single Cell Transcriptomics

    Speaker: Dr. Blake M. Warner, PhD, MPH, DDS – National Institutes of Health

  • 9:30 AM - 9:45 AM PT
    Differentially Expressed Gene Pathways in the Conjunctiva of Sjögren's Syndrome Keratoconjunctivitis Sicca

    Speaker: Cintia S. De Paiva, MD, PhD – Baylor College of Medicine

  • 9:45 AM - 10:00 AM PT
    Q&A